A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies

Faster, higher throughput antibody engineering methods are needed. Here the authors present CeVICA, a cell-free nanobody engineering platform using ribosome display and computational clustering analysis for in vitro selection; they use this to develop nanobodies against the RBD of SARS-CoV-2 spike p...

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Bibliographic Details
Main Authors: Xun Chen, Matteo Gentili, Nir Hacohen, Aviv Regev
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25777-z