High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

Proteomic technologies have identified 234 peptidases in plasma but little quantitative information about the proteolytic activity has been uncovered. In this study, the substrate profile of plasma proteases was evaluated using two nano-LC-ESI-MS/MS methods. Multiplex substrate profiling by mass spe...

Full description

Bibliographic Details
Main Authors: Elisa Maffioli, Zhenze Jiang, Simona Nonnis, Armando Negri, Valentina Romeo, Christopher B. Lietz, Vivian Hook, Giuseppe Ristagno, Giuseppe Baselli, Erik B. Kistler, Federico Aletti, Anthony J. O’Donoghue, Gabriella Tedeschi
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
peptidomics
mass spectrometry
plasma
aminopeptidase
carboxypeptidase
endoprotease
Online Access:https://www.mdpi.com/1420-3049/25/18/4071

Internet

https://www.mdpi.com/1420-3049/25/18/4071

Similar Items