KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation
The metabolic myocardium is an omnivore and utilizes various carbon substrates to meet its energetic demand. While the adult heart preferentially consumes fatty acids (FAs) over carbohydrates, myocardial fuel plasticity is essential for organismal survival. This metabolic plasticity governing fuel u...
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Online Access: | http://dx.doi.org/10.1155/2015/201625 |
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doaj-571477568f3f4cdca602eeb4916aa7a42020-11-25T00:28:42ZengHindawi LimitedPPAR Research1687-47571687-47652015-01-01201510.1155/2015/201625201625KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and OxidationDomenick A. Prosdocimo0Jenine E. John1Lilei Zhang2Elizabeth S. Efraim3Rongli Zhang4Xudong Liao5Mukesh K. Jain6Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, Cleveland, OH 44106, USACase Cardiovascular Research Institute and Harrington Heart & Vascular Institute, Cleveland, OH 44106, USACase Cardiovascular Research Institute and Harrington Heart & Vascular Institute, Cleveland, OH 44106, USACase Cardiovascular Research Institute and Harrington Heart & Vascular Institute, Cleveland, OH 44106, USACase Cardiovascular Research Institute and Harrington Heart & Vascular Institute, Cleveland, OH 44106, USACase Cardiovascular Research Institute and Harrington Heart & Vascular Institute, Cleveland, OH 44106, USACase Cardiovascular Research Institute and Harrington Heart & Vascular Institute, Cleveland, OH 44106, USAThe metabolic myocardium is an omnivore and utilizes various carbon substrates to meet its energetic demand. While the adult heart preferentially consumes fatty acids (FAs) over carbohydrates, myocardial fuel plasticity is essential for organismal survival. This metabolic plasticity governing fuel utilization is under robust transcriptional control and studies over the past decade have illuminated members of the nuclear receptor family of factors (e.g., PPARα) as important regulators of myocardial lipid metabolism. However, given the complexity of myocardial metabolism in health and disease, it is likely that other molecular pathways are likely operative and elucidation of such pathways may provide the foundation for novel therapeutic approaches. We previously demonstrated that Kruppel-like factor 15 (KLF15) is an independent regulator of cardiac lipid metabolism thus raising the possibility that KLF15 and PPARα operate in a coordinated fashion to regulate myocardial gene expression requisite for lipid oxidation. In the current study, we show that KLF15 binds to, cooperates with, and is required for the induction of canonical PPARα-mediated gene expression and lipid oxidation in cardiomyocytes. As such, this study establishes a molecular module involving KLF15 and PPARα and provides fundamental insights into the molecular regulation of cardiac lipid metabolism.http://dx.doi.org/10.1155/2015/201625 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Domenick A. Prosdocimo Jenine E. John Lilei Zhang Elizabeth S. Efraim Rongli Zhang Xudong Liao Mukesh K. Jain |
spellingShingle |
Domenick A. Prosdocimo Jenine E. John Lilei Zhang Elizabeth S. Efraim Rongli Zhang Xudong Liao Mukesh K. Jain KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation PPAR Research |
author_facet |
Domenick A. Prosdocimo Jenine E. John Lilei Zhang Elizabeth S. Efraim Rongli Zhang Xudong Liao Mukesh K. Jain |
author_sort |
Domenick A. Prosdocimo |
title |
KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation |
title_short |
KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation |
title_full |
KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation |
title_fullStr |
KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation |
title_full_unstemmed |
KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation |
title_sort |
klf15 and pparα cooperate to regulate cardiomyocyte lipid gene expression and oxidation |
publisher |
Hindawi Limited |
series |
PPAR Research |
issn |
1687-4757 1687-4765 |
publishDate |
2015-01-01 |
description |
The metabolic myocardium is an omnivore and utilizes various carbon substrates to meet its energetic demand. While the adult heart preferentially consumes fatty acids (FAs) over carbohydrates, myocardial fuel plasticity is essential for organismal survival. This metabolic plasticity governing fuel utilization is under robust transcriptional control and studies over the past decade have illuminated members of the nuclear receptor family of factors (e.g., PPARα) as important regulators of myocardial lipid metabolism. However, given the complexity of myocardial metabolism in health and disease, it is likely that other molecular pathways are likely operative and elucidation of such pathways may provide the foundation for novel therapeutic approaches. We previously demonstrated that Kruppel-like factor 15 (KLF15) is an independent regulator of cardiac lipid metabolism thus raising the possibility that KLF15 and PPARα operate in a coordinated fashion to regulate myocardial gene expression requisite for lipid oxidation. In the current study, we show that KLF15 binds to, cooperates with, and is required for the induction of canonical PPARα-mediated gene expression and lipid oxidation in cardiomyocytes. As such, this study establishes a molecular module involving KLF15 and PPARα and provides fundamental insights into the molecular regulation of cardiac lipid metabolism. |
url |
http://dx.doi.org/10.1155/2015/201625 |
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