KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation

KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation

The metabolic myocardium is an omnivore and utilizes various carbon substrates to meet its energetic demand. While the adult heart preferentially consumes fatty acids (FAs) over carbohydrates, myocardial fuel plasticity is essential for organismal survival. This metabolic plasticity governing fuel u...

Full description

Bibliographic Details
Main Authors:	Domenick A. Prosdocimo, Jenine E. John, Lilei Zhang, Elizabeth S. Efraim, Rongli Zhang, Xudong Liao, Mukesh K. Jain
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	PPAR Research
Online Access:	http://dx.doi.org/10.1155/2015/201625

Similar Items

KLF15 Establishes the Landscape of Diurnal Expression in the Heart
by: Lilei Zhang, et al.
Published: (2015-12-01)

Adipose KLF15 Controls Lipid Handling to Adapt to Nutrient Availability
by: Keiichiro Matoba, et al.
Published: (2017-12-01)

KLF15 Regulates Oxidative Stress Response in Cardiomyocytes through NAD<sup>+</sup>
by: Le Li, et al.
Published: (2021-09-01)

KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
by: Dae Young Jung, et al.
Published: (2013-01-01)

A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction
by: Paishiun N. Hsieh, et al.
Published: (2017-10-01)

Mechanisms underlying the interaction between PPARα and NADPH oxidases in the hypertrophic cardiomyocyte
by: Harvey
Published: (2014)

Extracellular Pyrophosphate Homeostasis and Regulation of Vascular Calcification in Vascular Smooth Muscle Cells
by: Prosdocimo, Domenick A.
Published: (2010)

Targeting Peroxisome Proliferator Activated Receptor α (PPAR α) for the Prevention of Mitochondrial Impairment and Hypertrophy in Cardiomyocytes
by: Dipak Kar, et al.
Published: (2018-08-01)

Effect of Berberine on PPARα/NO Activation in High Glucose- and Insulin-Induced Cardiomyocyte Hypertrophy
by: Mingfeng Wang, et al.
Published: (2013-01-01)

Bilirubin Binding to PPARα Inhibits Lipid Accumulation.
by: David E Stec, et al.
Published: (2016-01-01)

Role of PPAR-α in BMSO modulated lipid metabolism
by: Ya-Yuan Chang, et al.
Published: (2015)

Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis
by: Lei XiaoTian, et al.
Published: (2016-01-01)

Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk
by: Rohit A. Sinha, et al.
Published: (2020-03-01)

PPARα is essential for retinal lipid metabolism and neuronal survival
by: Elizabeth A. Pearsall, et al.
Published: (2017-11-01)

Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway
by: Xu Chen, et al.
Published: (2019-12-01)

Correlation of A2bAR and KLF4/KLF15 with Obesity-Dyslipidemia Induced Inflammation in Uygur Population
by: Cuizhe Wang, et al.
Published: (2016-01-01)

Role of PPARα and HNF4α in stress-mediated alterations in lipid homeostasis.
by: Maria Konstandi, et al.
Published: (2013-01-01)

Inhibition of pulmonary β-carotene 15, 15'-oxygenase expression by glucocorticoid involves PPARα.
by: Xiaoming Gong, et al.
Published: (2017-01-01)

Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα
by: Anne P.L. Jensen-Urstad, et al.
Published: (2013-07-01)

The Correlation of PPARα Activity and Cardiomyocyte Metabolism and Structure in Idiopathic Dilated Cardiomyopathy during Heart Failure Progression
by: E. Czarnowska, et al.
Published: (2016-01-01)

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes.
by: Jessica R Ivy, et al.
Published: (2015-01-01)

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses
by: Nadia Bougarne, et al.
Published: (2019-08-01)

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting
by: Yoshinori Takeuchi, et al.
Published: (2016-08-01)

Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation
by: Jian Liu, et al.
Published: (2011-01-01)

Scaffold-based pan-agonist design for the PPARα, PPARβ and PPARγ receptors.
by: Li-Song Zhang, et al.
Published: (2012-01-01)

Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation
by: Claudia Noack, et al.
Published: (2017-08-01)

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
by: Lise Van Wyngene, et al.
Published: (2020-02-01)

PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction
by: Xiaozhe Yin, et al.
Published: (2020-10-01)

The HIF-2α/PPARα pathway is essential for liraglutide-alleviated, lipid-induced hepatic steatosis
by: Hou Wang, et al.
Published: (2021-08-01)

Effects of PPARs agonists on cardiac metabolism in littermate and cardiomyocyte-specific PPAR-γ-knockout (CM-PGKO) mice.
by: Michelangela Barbieri, et al.
Published: (2012-01-01)

Histone Deacetylase 11 Contributes to Renal Fibrosis by Repressing KLF15 Transcription
by: Lei Mao, et al.
Published: (2020-04-01)

IL-15 Mediates Mitochondrial Activity through a PPARδ-Dependent-PPARα-Independent Mechanism in Skeletal Muscle Cells
by: Shantaé M. Thornton, et al.
Published: (2016-01-01)

PPARα-Independent Arterial Smooth Muscle Relaxant Effects of PPARα Agonists
by: Neerupma Silswal, et al.
Published: (2012-01-01)

The Partial Role of KLF4 and KLF5 in Gastrointestinal Tumors
by: Jun-Chen Li, et al.
Published: (2021-01-01)

Long noncoding RNA FTX ameliorates hydrogen peroxide-induced cardiomyocyte injury by regulating the miR-150/KLF13 axis
by: Zhang Yamin, et al.
Published: (2020-12-01)

Icariin Is A PPARα Activator Inducing Lipid Metabolic Gene Expression in Mice
by: Yuan-Fu Lu, et al.
Published: (2014-11-01)

Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function
by: Jia Wang, et al.
Published: (2020-04-01)

Tanshinol Rescues the Impaired Bone Formation Elicited by Glucocorticoid Involved in KLF15 Pathway
by: Yajun Yang, et al.
Published: (2016-01-01)

Sp1 and KLF15 regulate basal transcription of the human <it>LRP5 </it>gene
by: Zou Yongxin, et al.
Published: (2010-02-01)

An Ideal PPAR Response Element Bound to and Activated by PPARα.
by: John Tzeng, et al.
Published: (2015-01-01)