Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

Abstract Screening for effective candidate drugs for breast cancer has shifted from two-dimensional (2D) to three-dimensional (3D) cultures. Here we systematically compared the transcriptomes of these different culture conditions by RNAseq of 14 BC cell lines cultured in both 2D and 3D conditions. A...

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Bibliographic Details
Main Authors: Esmee Koedoot, Liesanne Wolters, Marcel Smid, Peter Stoilov, Gerhard A. Burger, Bram Herpers, Kuan Yan, Leo S. Price, John W. M. Martens, Sylvia E. Le Dévédec, Bob van de Water
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86664-7

Internet

https://doi.org/10.1038/s41598-021-86664-7

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