Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

Summary: Immune suppression by CD4+FOXP3+ regulatory T (Treg) cells and tumor infiltration by CD8+ effector T cells represent two major factors impacting response to cancer immunotherapy. Using deconvolution-based transcriptional profiling of human papilloma virus (HPV)-negative oral squamous cell c...

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Bibliographic Details
Main Authors: Jaime L. Chao, Michael Korzinkin, Alex Zhavoronkov, Ivan V. Ozerov, Matthew T. Walker, Kathleen Higgins, Mark W. Lingen, Evgeny Izumchenko, Peter A. Savage
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports Medicine
Subjects:
regulatory T cells
cancer immunology
oral squamous cell carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121002573

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http://www.sciencedirect.com/science/article/pii/S2666379121002573

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