Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids

Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids

Abstract The prognosis of locally advanced colorectal cancer (CRC) is currently unsatisfactory. This is mainly due to drug resistance, recurrence, and subsequent metastatic dissemination, which are sustained by the cancer stem cell (CSC) population. The main driver of the CSC gene expression program...

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Bibliographic Details
Main Authors: Martina Lepore Signorile, Valentina Grossi, Simone Di Franco, Giovanna Forte, Vittoria Disciglio, Candida Fasano, Paola Sanese, Katia De Marco, Francesco Claudio Susca, Laura Rosa Mangiapane, Annalisa Nicotra, Gabriella Di Carlo, Francesco Dituri, Gianluigi Giannelli, Giuseppe Ingravallo, Gianluca Canettieri, Giorgio Stassi, Cristiano Simone
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03572-4

Internet

https://doi.org/10.1038/s41419-021-03572-4

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