Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

Summary: Stresses associated with disease may pathologically remodel the proteome by both increasing interaction strength and altering interaction partners, resulting in proteome-wide connectivity dysfunctions. Chaperones play an important role in these alterations, but how these changes are execute...

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Bibliographic Details
Main Authors: Pengrong Yan, Hardik J. Patel, Sahil Sharma, Adriana Corben, Tai Wang, Palak Panchal, Chenghua Yang, Weilin Sun, Thais L. Araujo, Anna Rodina, Suhasini Joshi, Kenneth Robzyk, Srinivasa Gandu, Julie R. White, Elisa de Stanchina, Shanu Modi, Yelena Y. Janjigian, Elizabeth G. Hill, Bei Liu, Hediye Erdjument-Bromage, Thomas A. Neubert, Nanette L.S. Que, Zihai Li, Daniel T. Gewirth, Tony Taldone, Gabriela Chiosis
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
chaperome-mediated protein connectivity dysfunction
epichaperome
stress-mediated molecular dysfunction
protein mis-assembly
stable protein assembly
targeted protein degradation-based therapeutics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308214

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http://www.sciencedirect.com/science/article/pii/S2211124720308214

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