HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

The identification of mRNA targets for RNA binding proteins (RBP) in stem cells is difficult due to the limited number of available cells. Here, as a proof-of-principle, the authors adapt the HyperTRIBE method to find that an RBP, MSI2, has increased RNA binding in leukemic compared with normal stem...

Full description

Bibliographic Details
Main Authors: Diu T. T. Nguyen, Yuheng Lu, Karen L. Chu, Xuejing Yang, Sun-Mi Park, Zi-Ning Choo, Christopher R. Chin, Camila Prieto, Alexandra Schurer, Ersilia Barin, Angela M. Savino, Saroj Gourkanti, Payal Patel, Ly P. Vu, Christina S. Leslie, Michael G. Kharas
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15814-8

Internet

https://doi.org/10.1038/s41467-020-15814-8

Similar Items