Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance

Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance

Aging is associated with cognitive decline and decreased concentrations of short-chain fatty acids (SCFAs) in the gut. SCFAs are significant in that they are protective to the gut and other organs. We tested the hypothesis that the aged gut microbiome alone is sufficient to decrease SCFAs in the hos...

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Bibliographic Details
Main Authors: Juneyoung Lee, Venugopal R. Venna, David J. Durgan, Huanan Shi, Jacob Hudobenko, Nagireddy Putluri, Joseph Petrosino, Louise D. McCullough, Robert M. Bryan
Format: Article
Language:English
Published: Taylor & Francis Group 2020-11-01
Series:Gut Microbes
Subjects:
aging
gut microbiome
short-chain fatty acids
acetate
propionate
butyrate
inflammation
germ-free mice
cognitive decline
Online Access:http://dx.doi.org/10.1080/19490976.2020.1814107

Internet

http://dx.doi.org/10.1080/19490976.2020.1814107

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