Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

Abstract Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as accompanying neuron loss. We explored if cortical neurons detected by NeuN decreased with increasing TDP-43 inclu...

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Bibliographic Details
Main Authors: Ahmed Yousef, John L. Robinson, David J. Irwin, Matthew D. Byrne, Linda K. Kwong, Edward B. Lee, Yan Xu, Sharon X. Xie, Lior Rennert, EunRan Suh, Vivianna M. Van Deerlin, Murray Grossman, Virginia M.-Y. Lee, John Q. Trojanowski
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Acta Neuropathologica Communications
Subjects:
TDP-43
C9orf72
GRN
Frontotemporal lobar degeneration
NeuN
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s40478-017-0471-3

Internet

http://link.springer.com/article/10.1186/s40478-017-0471-3

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