Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration
Abstract Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as accompanying neuron loss. We explored if cortical neurons detected by NeuN decreased with increasing TDP-43 inclu...
Main Authors: | Ahmed Yousef, John L. Robinson, David J. Irwin, Matthew D. Byrne, Linda K. Kwong, Edward B. Lee, Yan Xu, Sharon X. Xie, Lior Rennert, EunRan Suh, Vivianna M. Van Deerlin, Murray Grossman, Virginia M.-Y. Lee, John Q. Trojanowski |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-09-01
|
Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40478-017-0471-3 |
Similar Items
-
Experimental Disease-Modifying Agents for Frontotemporal Lobar Degeneration
by: Giunta M, et al.
Published: (2021-03-01) -
Imaging Biomarkers for Neurodegeneration in Presymptomatic Familial Frontotemporal Lobar Degeneration
by: Qin Chen, et al.
Published: (2020-02-01) -
Neuropathology of frontotemporal lobar degeneration: A review
by: Valéria Santoro Bahia, et al. -
Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations
by: Kocerha Jannet, et al.
Published: (2011-10-01) -
Frontotemporal Lobar Degeneration and microRNAs
by: Paola ePiscopo, et al.
Published: (2016-02-01)