Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist

Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe X-linked neurodevelopmental encephalopathy caused by mutations in the CDKL5 gene and characterized by early-onset epilepsy and intellectual and motor impairments. No cure is currently available for CDD patients, as limited...

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Bibliographic Details
Main Authors: Elisa Ren, Vincenzo Roncacé, Stefania Trazzi, Claudia Fuchs, Giorgio Medici, Laura Gennaccaro, Manuela Loi, Giuseppe Galvani, Keqiang Ye, Roberto Rimondini, Giorgio Aicardi, Elisabetta Ciani
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CDKL5
synaptic plasticity
TrkB
PLCγ1
dendritic pattern
GluA2
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00169/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00169/full

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