A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model

A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model

Abstract Background Tuberous sclerosis complex (TSC) is a rare monogenic disorder characterized by benign tumors in multiple organs as well as a high prevalence of epilepsy, intellectual disability and autism. TSC is caused by inactivating mutations in the TSC1 or TSC2 genes. Heterozygocity induces...

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Bibliographic Details
Main Authors: Hendrik Wesseling, Ype Elgersma, Sabine Bahn
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Molecular Autism
Subjects:
Tuberous sclerosis
Rapamycin
Proteomics
SRM
Animal model
Online Access:http://link.springer.com/article/10.1186/s13229-017-0151-y

Internet

http://link.springer.com/article/10.1186/s13229-017-0151-y

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