Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth

Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth

Runxiang Qiu et al find that conditional knockout of Kif20a, a regulator of cytokinesis and neural progenitor cell fate, induces early cell cycle exit and precocious neuronal differentiation of cerebellar granule neuron progenitors. They show that Kif20a depletion suppresses tumour formation in gene...

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Main Authors: Runxiang Qiu, Jun Wu, Brian Gudenas, Paul A. Northcott, Robert J. Wechsler-Reya, Qiang Lu
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02075-4
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spelling doaj-587dca441c9e4d268442fa115aeff8142021-05-11T14:54:37ZengNature Publishing GroupCommunications Biology2399-36422021-05-014111210.1038/s42003-021-02075-4Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growthRunxiang Qiu0Jun Wu1Brian Gudenas2Paul A. Northcott3Robert J. Wechsler-Reya4Qiang Lu5Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of HopeDivision of Comparative Medicine, Beckman Research Institute of the City of HopeDepartment of Developmental Neurobiology, St. Jude Children’s Research HospitalDepartment of Developmental Neurobiology, St. Jude Children’s Research HospitalTumor Initiation and Maintenance Program, National Cancer Institute–Designated Cancer Center, Sanford Burnham Prebys Medical Discovery InstituteDepartment of Developmental and Stem Cell Biology, Beckman Research Institute of the City of HopeRunxiang Qiu et al find that conditional knockout of Kif20a, a regulator of cytokinesis and neural progenitor cell fate, induces early cell cycle exit and precocious neuronal differentiation of cerebellar granule neuron progenitors. They show that Kif20a depletion suppresses tumour formation in genetic and xenograft mouse models of medulloblastoma, indicating the value of targeting daughter cell fate specification.https://doi.org/10.1038/s42003-021-02075-4
collection DOAJ
language English
format Article
sources DOAJ
author Runxiang Qiu
Jun Wu
Brian Gudenas
Paul A. Northcott
Robert J. Wechsler-Reya
Qiang Lu
spellingShingle Runxiang Qiu
Jun Wu
Brian Gudenas
Paul A. Northcott
Robert J. Wechsler-Reya
Qiang Lu
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
Communications Biology
author_facet Runxiang Qiu
Jun Wu
Brian Gudenas
Paul A. Northcott
Robert J. Wechsler-Reya
Qiang Lu
author_sort Runxiang Qiu
title Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_short Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_full Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_fullStr Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_full_unstemmed Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
title_sort depletion of kinesin motor kif20a to target cell fate control suppresses medulloblastoma tumour growth
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-05-01
description Runxiang Qiu et al find that conditional knockout of Kif20a, a regulator of cytokinesis and neural progenitor cell fate, induces early cell cycle exit and precocious neuronal differentiation of cerebellar granule neuron progenitors. They show that Kif20a depletion suppresses tumour formation in genetic and xenograft mouse models of medulloblastoma, indicating the value of targeting daughter cell fate specification.
url https://doi.org/10.1038/s42003-021-02075-4
work_keys_str_mv AT runxiangqiu depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth
AT junwu depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth
AT briangudenas depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth
AT paulanorthcott depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth
AT robertjwechslerreya depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth
AT qianglu depletionofkinesinmotorkif20atotargetcellfatecontrolsuppressesmedulloblastomatumourgrowth
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