Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth

by Runxiang Qiu, Jun Wu, Brian Gudenas, Paul A. Northcott, Robert J. Wechsler-Reya, Qiang Lu
Published 2021-05-01

Proteomic analysis of Medulloblastoma reveals functional biology with translational potential

by Samuel Rivero-Hinojosa, Ling San Lau, Mojca Stampar, Jerome Staal, Huizhen Zhang, Heather Gordish-Dressman, Paul A. Northcott, Stefan M. Pfister, Michael D. Taylor, Kristy J. Brown, Brian R. Rood
Published 2018-06-01

Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma

by Victor Maximov, Zhihong Chen, Yun Wei, M. Hope Robinson, Cameron J. Herting, Nithya S. Shanmugam, Vasilisa A. Rudneva, Kelly C. Goldsmith, Tobey J. MacDonald, Paul A. Northcott, Dolores Hambardzumyan, Anna M. Kenney
Published 2019-06-01

Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma

by Yukiko Nakahara, Paul A. Northcott, Meihua Li, Paul N. Kongkham, Christian Smith, Hai Yan, Sidney Croul, Young-Shin Ra, Charles Eberhart, Annie Huang, Darell Bigner, Wesia Grajkowska, Timothy Van Meter, James T. Rutka, Michael D. Taylor
Published 2010-01-01

TelomereHunter – in silico estimation of telomere content and composition from cancer genomes

by Lars Feuerbach, Lina Sieverling, Katharina I. Deeg, Philip Ginsbach, Barbara Hutter, Ivo Buchhalter, Paul A. Northcott, Sadaf S. Mughal, Priya Chudasama, Hanno Glimm, Claudia Scholl, Peter Lichter, Stefan Fröhling, Stefan M. Pfister, David T. W. Jones, Karsten Rippe, Benedikt Brors
Published 2019-05-01

Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma

by BaoHan T. Vo, Chunliang Li, Marc A. Morgan, Ilan Theurillat, David Finkelstein, Shaela Wright, Judith Hyle, Stephanie M.C. Smith, Yiping Fan, Yong-Dong Wang, Gang Wu, Brent A. Orr, Paul A. Northcott, Ali Shilatifard, Charles J. Sherr, Martine F. Roussel
Published 2017-03-01

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

by Catherine Lee, Vasilisa A. Rudneva, Serap Erkek, Marc Zapatka, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Alexandra Garancher, Jessica M. Rusert, Ozlem Aksoy, Robin Lea, Helai P. Mohammad, Jianxun Wang, William A. Weiss, H. Leighton Grimes, Stefan M. Pfister, Paul A. Northcott, Robert J. Wechsler-Reya
Published 2019-01-01

MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma.

by Livia Garzia, Immacolata Andolfo, Emilio Cusanelli, Natascia Marino, Giuseppe Petrosino, Daniela De Martino, Veronica Esposito, Aldo Galeone, Luigi Navas, Silvia Esposito, Sara Gargiulo, Sarah Fattet, Vittoria Donofrio, Giuseppe Cinalli, Arturo Brunetti, Luigi Del Vecchio, Paul A Northcott, Olivier Delattre, Michael D Taylor, Achille Iolascon, Massimo Zollo
Published 2009-01-01

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

by Jennifer Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Published 2019-12-01

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

by Weijun Feng, Daisuke Kawauchi, Huiqin Körkel-Qu, Huan Deng, Elisabeth Serger, Laura Sieber, Jenna Ariel Lieberman, Silvia Jimeno-González, Sander Lambo, Bola S. Hanna, Yassin Harim, Malin Jansen, Anna Neuerburg, Olga Friesen, Marc Zuckermann, Vijayanad Rajendran, Jan Gronych, Olivier Ayrault, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Peter Lichter, Felipe Cortés-Ledesma, Stefan M. Pfister, Hai-Kun Liu
Published 2017-03-01

Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation

by Erin A Bassett, Nicholas Tokarew, Ema A Allemano, Chantal Mazerolle, Katy Morin, Alan J Mears, Brian McNeill, Randy Ringuette, Charles Campbell, Sheila Smiley, Neno T Pokrajac, Adrian M Dubuc, Vijay Ramaswamy, Paul A Northcott, Marc Remke, Philippe P Monnier, David Potter, Kim Paes, Laura L Kirkpatrick, Kenneth J Coker, Dennis S Rice, Carol Perez-Iratxeta, Michael D Taylor, Valerie A Wallace
Published 2016-11-01

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma

by Chen He, Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin, Nathaniel Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn H. Kasper, Junyuan Zhang, Xiaoyu Li, James Dalton, Barbara Jonchere, Kimberly S. Mercer, Duane G. Currier, William Caufield, Yingzhe Wang, Jia Xie, Alberto Broniscer, Cynthia Wetmore, Santhosh A. Upadhyaya, Ibrahim Qaddoumi, Paul Klimo, Frederick Boop, Amar Gajjar, Jinghui Zhang, Brent A. Orr, Giles W. Robinson, Michelle Monje, Burgess B. Freeman III, Martine F. Roussel, Paul A. Northcott, Taosheng Chen, Zoran Rankovic, Gang Wu, Jason Chiang, Christopher L. Tinkle, Anang A. Shelat, Suzanne J. Baker
Published 2021-07-01

Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

by Liana Nobre, Michal Zapotocky, Sara Khan, Kohei Fukuoka, Adriana Fonseca, Tara McKeown, David Sumerauer, Ales Vicha, Wieslawa A. Grajkowska, Joanna Trubicka, Kay Ka Wai Li, Ho-Keung Ng, Luca Massimi, Ji Yeoun Lee, Seung-Ki Kim, Shayna Zelcer, Alexandre Vasiljevic, Cécile Faure-Conter, Peter Hauser, Boleslaw Lach, Marie-Lise van Veelen-Vincent, Pim J. French, Erwin G. Van Meir, William A. Weiss, Nalin Gupta, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, Joshua B. Rubin, Andrew S. Moore, Lola B. Chambless, Rajeev Vibhakar, Young Shin Ra, Maura Massimino, Roger E. McLendon, Helen Wheeler, Massimo Zollo, Veronica Ferruci, Toshihiro Kumabe, Claudia C. Faria, Jaroslav Sterba, Shin Jung, Enrique López-Aguilar, Jaume Mora, Carlos G. Carlotti, James M. Olson, Sarah Leary, Jason Cain, Lenka Krskova, Josef Zamecnik, Cynthia E. Hawkins, Uri Tabori, Annie Huang, Ute Bartels, Paul A. Northcott, Michael D. Taylor, Stephen Yip, Jordan R. Hansford, Eric Bouffet, Vijay Ramaswamy
Published 2020-06-01