A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

The microtubule-associated protein Tau is strongly implicated in Alzheimer's disease (AD) and aggregates into neurofibrillary tangles in AD. Genetic reduction of Tau is protective in several animal models of AD and cell culture models of amyloid-β (Aβ) toxicity, making it an exciting therapeuti...

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Bibliographic Details
Main Authors: Travis Rush, Jonathan R. Roth, Samantha J. Thompson, Adam R. Aldaher, J. Nicholas Cochran, Erik D. Roberson
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Subjects:
Amyloid-β
Oligomer
Tau
SH3
Fyn
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303432

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http://www.sciencedirect.com/science/article/pii/S0969996119303432

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