In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation

In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation

Host Defense Peptides (HDPs) are key components of innate immunity that exert antimicrobial, antibiofilm, and immunomodulatory activities in all higher organisms. Synthetic peptidomimetic analogs were designed to retain the desirable pharmacological properties of HDPs while having improved stability...

Full description

Bibliographic Details
Main Authors: Bing C. Wu, Sarah L. Skovbakke, Hamid Masoudi, Robert E. W. Hancock, Henrik Franzyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
peptidomimetics
anti-inflammatory
phorbol 12-myristate 13-acetate
sterile inflammation
formyl peptide receptors
edema
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02102/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02102/full

Similar Items