Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models

Background: A tetravalent live attenuated dengue vaccine, Dengvaxia, sensitised naïve recipients to severe dengue illness upon a subsequent natural dengue infection and is suspected to be due to antibody-dependent enhancement (ADE). ADE has also been implicated in the severe neurological outcomes of...

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Bibliographic Details
Main Authors: Rahul Shukla, Hemalatha Beesetti, Julia A. Brown, Richa Ahuja, Viswanathan Ramasamy, Rajgokul K. Shanmugam, Ankur Poddar, Gaurav Batra, Florian Krammer, Jean K. Lim, Sachin Kale, Altaf A. Lal, Sathyamangalam Swaminathan, Navin Khanna
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:EBioMedicine
Subjects:
LAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303674