Forming megakaryocytes from murine induced pluripotent stem cells by the inducible overexpression of supporting factors

Forming megakaryocytes from murine induced pluripotent stem cells by the inducible overexpression of supporting factors

Abstract Background Platelets are small anucleate cells that circulate in the blood in a resting state but can be activated by external cues. In case of need, platelets from blood donors can be transfused. As an alternative source, platelets can be produced from induced pluripotent stem cells (iPSCs...

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Bibliographic Details
Main Authors: Katharina Cullmann, Magdalena Jahn, Markus Spindler, Franziska Schenk, Georgi Manukjan, Adele Mucci, Doris Steinemann, Klaus Boller, Harald Schulze, Markus Bender, Thomas Moritz, Ute Modlich
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
Genetic modification
iPS cells
megakaryocytes
retroviral vectors
Tet‐inducible system
Online Access:https://doi.org/10.1002/rth2.12453

Internet

https://doi.org/10.1002/rth2.12453

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