Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis

Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and no curative therapies. SCF-Skp2 E3 ligase is a target for cancer therapy, but there have been no reports about Skp2 as a target for IPF. Here we demonstrate that Skp2 is a promising therapeutic target for IPF. We ex...

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Bibliographic Details
Main Authors: Masashi Mikamo, Kyoko Kitagawa, Satoshi Sakai, Chiharu Uchida, Tatsuya Ohhata, Koji Nishimoto, Hiroyuki Niida, Sayuri Suzuki, Keiichi I. Nakayama, Naoki Inui, Takafumi Suda, Masatoshi Kitagawa
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
Skp2
E3 ligase
p27
bleomycin
pulmonary fibrosis
mouse model
chemical inhibitor
idiopathic pulmonary fibrosis (IPF)
Online Access:http://www.mdpi.com/1422-0067/19/2/474

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http://www.mdpi.com/1422-0067/19/2/474

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