Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis

Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis

Despite the enormous morbidity attributed to schistosomiasis, there is still no vaccine to combat the disease for the hundreds of millions of infected people. The anthelmintic drug, praziquantel, is the mainstay treatment option, although its molecular mechanism of action remains poorly defined. Pra...

Full description

Bibliographic Details
Main Authors: Mark S. Pearson, Bemnet A. Tedla, Luke Becker, Rie Nakajima, Al Jasinskas, Takafira Mduluza, Francisca Mutapi, Claude Oeuvray, Beatrice Greco, Javier Sotillo, Philip L. Felgner, Alex Loukas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
cystatin
praziquantel
proteome microarray
urogenital schistosomiasis
vaccine
immunomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.663041/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.663041/full

Similar Items