Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid-beta plaques. The presence and spread of tau pathology through the brain is classified by Braak stages and thought...

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Bibliographic Details
Main Authors: Sarah L. DeVos, Bianca T. Corjuc, Derek H. Oakley, Chloe K. Nobuhara, Riley N. Bannon, Alison Chase, Caitlin Commins, Jose A. Gonzalez, Patrick M. Dooley, Matthew P. Frosch, Bradley T. Hyman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Neuroscience
Subjects:
tau
seeding
propagation
synapses
aggregation
Alzheimer's disease
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00267/full

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http://journal.frontiersin.org/article/10.3389/fnins.2018.00267/full

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