Blockage of NLRP3 inflammasome activation ameliorates acute inflammatory injury and long-term cognitive impairment induced by necrotizing enterocolitis in mice

Blockage of NLRP3 inflammasome activation ameliorates acute inflammatory injury and long-term cognitive impairment induced by necrotizing enterocolitis in mice

Abstract Background Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal disease in premature neonates with high mortality and morbidity, while the underlining mechanism of intestinal injury and profound neurological dysfunction remains unclear. Here, we aimed to investigate the invol...

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Bibliographic Details
Main Authors: Fangxinxing Zhu, Lingyu Wang, Zizhen Gong, Yanyan Wang, Yanhong Gao, Wei Cai, Jin Wu
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Neuroinflammation
Subjects:
Neonatal necrotizing enterocolitis
NLRP3 inflammasome
IL-1β
Intestinal injury
Brain damage
Cognitive impairment
Online Access:https://doi.org/10.1186/s12974-021-02111-4

Internet

https://doi.org/10.1186/s12974-021-02111-4

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