Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease.

Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease.

Restorative/protective therapies to restore dopamine neurons in the substantia nigra pars compacta (SNpc) are greatly needed to effectively change the debilitating course of Parkinson's disease. In this study, we tested the therapeutic potential of a neurogenic neurosteroid, allopregnanolone, i...

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Bibliographic Details
Main Authors: Samuel O Adeosun, Xu Hou, Yun Jiao, Baoying Zheng, Sherry Henry, Rosanne Hill, Zhi He, Amar Pani, Patrick Kyle, Xiaoming Ou, Thomas Mosley, Jerry M Farley, Craig Stockmeier, Ian Paul, Steven Bigler, Roberta Diaz Brinton, Richard Smeyne, Jun Ming Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3510204?pdf=render

Internet

http://europepmc.org/articles/PMC3510204?pdf=render

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