Synaptic Alterations in Mouse Models for Alzheimer Disease—A Special Focus on N-Truncated Abeta 4-42

Synaptic Alterations in Mouse Models for Alzheimer Disease—A Special Focus on N-Truncated Abeta 4-42

This commentary reviews the role of the Alzheimer amyloid peptide Aβ on basal synaptic transmission, synaptic short-term plasticity, as well as short- and long-term potentiation in transgenic mice, with a special focus on N-terminal truncated Aβ4-42. Aβ4-42 is highly abundant in the brain of Alzheim...

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Bibliographic Details
Main Authors: Katharina Dietrich, Yvonne Bouter, Michael Müller, Thomas A. Bayer
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
Alzheimer’s disease
N-truncated Aβ
transgenic mouse models
long-term potentiation
electrophysiology
synapse
field potential
Tg4-42
Online Access:http://www.mdpi.com/1420-3049/23/4/718

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http://www.mdpi.com/1420-3049/23/4/718

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