Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation

Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation

BackgroundActivated protein C (APC), a serine protease with antithrombotic effects, protects in animal models of ischemic stroke by suppressing inflammation and enhancing vascular integrity, angiogenesis, neurogenesis and neuroprotection. A small number of animal studies suggest it might also have t...

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Bibliographic Details
Main Authors: Ravi Kant, Sebok K. Halder, Jose A. Fernández, John H. Griffin, Richard Milner
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neuroscience
Subjects:
activated protein C
experimental autoimmune encephalomyelitis
microglia
blood-brain barrier
vascular
matrix metalloproteinase-9
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00333/full

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https://www.frontiersin.org/article/10.3389/fnins.2020.00333/full

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