Unique Features and Anti-microbial Targeting of Folate- and Flavin-Dependent Methyltransferases Required for Accurate Maintenance of Genetic Information

Unique Features and Anti-microbial Targeting of Folate- and Flavin-Dependent Methyltransferases Required for Accurate Maintenance of Genetic Information

Comparative genome analyses have led to the discovery and characterization of novel flavin- and folate-dependent methyltransferases that mainly function in DNA precursor synthesis and post-transcriptional RNA modification by forming (ribo) thymidylate and its derivatives. Here we discuss the recent...

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Bibliographic Details
Main Authors: Hannu Myllykallio, Pierre Sournia, Alice Heliou, Ursula Liebl
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
thymidylate synthesis
RNA modification
flavoproteins
folate dependent methylation
Anti-bacterial Agents
bacterial virulence
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00918/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00918/full

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