Canonical WNT/β-Catenin Signaling Plays a Subordinate Role in Rhabdomyosarcomas

Canonical WNT/β-Catenin Signaling Plays a Subordinate Role in Rhabdomyosarcomas

The development of skeletal muscle from immature precursors is partially driven by canonical WNT/β-catenin signaling. Rhabdomyosarcomas (RMS) are immature skeletal muscle-like, highly lethal cancers with a variably pronounced blockade of muscle differentiation. To investigate whether canonical β-cat...

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Bibliographic Details
Main Authors: Nada Ragab, Florian Viehweger, Julia Bauer, Natalie Geyer, Mingya Yang, Anna Seils, Djeda Belharazem, Felix H. Brembeck, Hans-Ulrich Schildhaus, Alexander Marx, Heidi Hahn, Katja Simon-Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pediatrics
Subjects:
rhabdomyosarcoma
canonical WNT signaling
myodifferentiation
WNT3A
FH535
XAV939
Online Access:https://www.frontiersin.org/article/10.3389/fped.2018.00378/full

Internet

https://www.frontiersin.org/article/10.3389/fped.2018.00378/full

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