Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus

Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus

Expression of urokinase-type plasminogen activator (uPA) is increased after brain injury, suggesting that, like in cancer tissue, uPA plays roles in brain remodeling. Here we injured brain with intrahippocampal kainic acid (KA) injection in adult Wt and uPA−/− mice. At 20 days post-injury, uPA−/− mi...

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Bibliographic Details
Main Authors: Laura Lahtinen, Xavier Ekolle Ndode-Ekane, Filip Barinka, Yumiko Akamine, Mohammed Hossein Esmaeili, Jukka Rantala, Asla Pitkänen
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Neurobiology of Disease
Subjects:
Angiogenesis
Epilepsy
Epileptogenesis
Granule cell dispersion
Hippocampus
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109003635

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http://www.sciencedirect.com/science/article/pii/S0969996109003635

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