mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo

mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo

Introduction: Spondyloarthritis (SpA) is characterized by inflammation, articular bone erosions and pathologic new bone formation. Targeting TNFα or IL-17A with current available therapies reduces inflammation in SpA, however, treatment of the bone pathology in SpA remains an unmet clinical need. Ac...

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Bibliographic Details
Main Authors: Sijia Chen, Melissa N. van Tok, Véronique L. Knaup, Lianne Kraal, Désiree Pots, Lina Bartels, Ellen M. Gravallese, Joel D. Taurog, Marleen van de Sande, Leonie M. van Duivenvoorde, Dominique L. Baeten
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
spondyloarthtritis
mTOR
rapamycin
IL-17A
fibroblast-like synoviocytes
small molecule treatment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02344/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02344/full

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