Glucocorticoid Resistant Pediatric Acute Lymphoblastic Leukemia Samples Display Altered Splicing Profile and Vulnerability to Spliceosome Modulation

Glucocorticoid Resistant Pediatric Acute Lymphoblastic Leukemia Samples Display Altered Splicing Profile and Vulnerability to Spliceosome Modulation

Glucocorticoid (GC) resistance is a crucial determinant of inferior response to chemotherapy in pediatric acute lymphoblastic leukemia (ALL); however, molecular mechanisms underlying this phenomenon are poorly understood. Deregulated splicing is a common feature of many cancers, which impacts drug r...

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Bibliographic Details
Main Authors: Rocco Sciarrillo, Anna Wojtuszkiewicz, Irsan E. Kooi, Leticia G. Leon, Edwin Sonneveld, Roland P. Kuiper, Gerrit Jansen, Elisa Giovannetti, Gertjan J.L. Kaspers, Jacqueline Cloos
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
alternative splicing
glucocorticoid resistance
pediatric acute lymphoblastic leukemia
rna sequencing
sf3b modulators
Online Access:https://www.mdpi.com/2072-6694/12/3/723

Internet

https://www.mdpi.com/2072-6694/12/3/723

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