The lysosomal protein cathepsin L is a progranulin protease

The lysosomal protein cathepsin L is a progranulin protease

Abstract Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has been shown to regulate brain PGRN levels, and complete deficiency of PGRN is a di...

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Bibliographic Details
Main Authors: Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, Leonard Petrucelli
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Molecular Neurodegeneration
Subjects:
Progranulin
Lysosome
Cathepsin L
Neutrophil elastase
Frontotemporal lobar degeneration
Neuronal ceroid lipofuscinosis
Online Access:http://link.springer.com/article/10.1186/s13024-017-0196-6

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http://link.springer.com/article/10.1186/s13024-017-0196-6

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