Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment

Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment

Breast cancer stem cells (BCSCs) play a critical role in tumor recurrence and metastasis. Exposure of breast cancer cells to chemotherapy leads to an enrichment of BCSCs. Here, we find that chemotherapy induces the expression of glutathione S-transferase omega 1 (GSTO1), which is dependent on hypoxi...

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Bibliographic Details
Main Authors: Haiquan Lu, Ivan Chen, Larissa A. Shimoda, Youngrok Park, Chuanzhao Zhang, Linh Tran, Huimin Zhang, Gregg L. Semenza
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
breast cancer stem cell
chemotherapy
hypoxia-inducible factors
pluripotency factors
tumor initiation
metastasis
tumor recurrence
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301651

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http://www.sciencedirect.com/science/article/pii/S2211124717301651

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