Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner
Mixed background SHP−/− mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC-1α expression in brown adipocytes. However, congenic SHP−/− mice on the C57BL/6 background showed normal expression of PGC-1α and other genes involved in brown adipose tissue...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2011-12-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520408272 |