Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner

Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner

Mixed background SHP−/− mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC-1α expression in brown adipocytes. However, congenic SHP−/− mice on the C57BL/6 background showed normal expression of PGC-1α and other genes involved in brown adipose tissue...

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Bibliographic Details
Main Authors: Young Joo Park, Seong Chul Kim, Jeehee Kim, Sayeepriyadarshini Anakk, Jae Man Lee, Hsiu-Ting Tseng, Vijay Yechoor, Junchol Park, June-Seek Choi, Hak Chul Jang, Ki-Up Lee, Colleen M. Novak, David D. Moore, Yoon Kwang Lee
Format: Article
Language:English
Published: Elsevier 2011-12-01
Series:Journal of Lipid Research
Subjects:
hepatic steatosis
β-oxidation
oxygen consumption
respiratory quotient
insulin sensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408272

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http://www.sciencedirect.com/science/article/pii/S0022227520408272

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