IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

Summary: Myeloid lineage cells use TLRs to recognize and respond to diverse microbial ligands. Although unique transcription factors dictate the outcome of specific TLR signaling, whether lineage-specific differences exist to further modulate the quality of TLR-induced inflammation remains unclear....

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Bibliographic Details
Main Authors: Ran Song, Yajing Gao, Igor Dozmorov, Venkat Malladi, Irene Saha, Margaret M. McDaniel, Sreeja Parameswaran, Chaoying Liang, Carlos Arana, Bo Zhang, Benjamin Wakeland, Jinchun Zhou, Matthew T. Weirauch, Leah C. Kottyan, Edward K. Wakeland, Chandrashekhar Pasare
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
macrophages
monocytes
human PBMCs
IRF1
interferon-stimulated genes
TLR4
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002059

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http://www.sciencedirect.com/science/article/pii/S2211124721002059

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