Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons

Abstract Mutations in PRKN are the most common cause of early onset Parkinson’s disease. Parkin is an E3 ubiquitin ligase, functioning in mitophagy. Mitochondrial abnormalities are present in PRKN mutant models. Patient derived neurons are a promising model in which to study pathogenic mechanisms an...

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Bibliographic Details
Main Authors: Aurelie Schwartzentruber, Camilla Boschian, Fernanda Martins Lopes, Monika A. Myszczynska, Elizabeth J. New, Julien Beyrath, Jan Smeitink, Laura Ferraiuolo, Heather Mortiboys
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-72345-4

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https://doi.org/10.1038/s41598-020-72345-4

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