γ-Protocadherin structural diversity and functional implications

γ-Protocadherin structural diversity and functional implications

Stochastic cell-surface expression of α-, β-, and γ-clustered protocadherins (Pcdhs) provides vertebrate neurons with single-cell identities that underlie neuronal self-recognition. Here we report crystal structures of ectodomain fragments comprising cell-cell recognition regions of mouse γ-Pcdhs γA...

Full description

Bibliographic Details
Main Authors: Kerry Marie Goodman, Rotem Rubinstein, Chan Aye Thu, Seetha Mannepalli, Fabiana Bahna, Göran Ahlsén, Chelsea Rittenhouse, Tom Maniatis, Barry Honig, Lawrence Shapiro
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
clustered protocadherins
crystal structure
protein-protein recognition
protein diversity
neuronal self-avoidance
Online Access:https://elifesciences.org/articles/20930

Internet

https://elifesciences.org/articles/20930

Similar Items