Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome.

Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome.

Therapeutic modulation of protein interactions is challenging, but short linear motifs (SLiMs) represent potential targets. Focal adhesions play a central role in adhesion by linking cells to the extracellular matrix. Integrins are central to this process, and many other intracellular proteins are c...

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Bibliographic Details
Main Authors: Kevin T O'Brien, Kalyan Golla, Tilen Kranjc, Darragh O'Donovan, Seamus Allen, Patricia Maguire, Jeremy C Simpson, David O'Connell, Niamh Moran, Denis C Shields
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210337

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https://doi.org/10.1371/journal.pone.0210337

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