PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer

PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer

Background In patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC), immune checkpoint blockade is ineffective, and combinatorial approaches enhancing immunogenicity need exploration.Methods We treated 43 patients with predominantly microsatellite stable RAS/BRAF wild-type mC...

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Bibliographic Details
Main Authors: Thomas J Ettrich, Barbara Seliger, Chiara Massa, Alexander Stein, Claudia Wickenhauser, Axel Hinke, Uwe Pelzer, Carsten Bokemeyer, Marcus Bauer, Susanna Hegewisch-Becker, Donjete Simnica, Christoph Schultheiß, Rebekka Scholz, Joseph Tintelnot, Eray Gökkurt, Lisa von Wenserski, Edith Willscher, Lisa Paschold, Markus Sauer, Sylvie Lorenzen, Jorge Riera-Knorrenschild, Reinhard Depenbusch, Steffen Dörfel, Salah-Eddin Al-Batran, Meinolf Karthaus, Lisa Waberer, Mascha Binder
Format: Article
Language:English
Published: BMJ Publishing Group 2021-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/7/e002844.full

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https://jitc.bmj.com/content/9/7/e002844.full

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