NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.

Bibliographic Details
Main Authors: Kristina Ludigs, Camilla Jandus, Daniel T. Utzschneider, Francesco Staehli, Stéphanie Bessoles, Anh Thu Dang, Giorgia Rota, Wilson Castro, Dietmar Zehn, Eric Vivier, Werner Held, Pedro Romero, Greta Guarda
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10554

Internet

https://doi.org/10.1038/ncomms10554

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