NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.

Bibliographic Details
Main Authors:	Kristina Ludigs, Camilla Jandus, Daniel T. Utzschneider, Francesco Staehli, Stéphanie Bessoles, Anh Thu Dang, Giorgia Rota, Wilson Castro, Dietmar Zehn, Eric Vivier, Werner Held, Pedro Romero, Greta Guarda
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10554

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spelling	doaj-5daa48a82f9b456488d8d66573ddc1162021-05-11T11:20:39ZengNature Publishing GroupNature Communications2041-17232016-02-017111010.1038/ncomms10554NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditionsKristina Ludigs0Camilla Jandus1Daniel T. Utzschneider2Francesco Staehli3Stéphanie Bessoles4Anh Thu Dang5Giorgia Rota6Wilson Castro7Dietmar Zehn8Eric Vivier9Werner Held10Pedro Romero11Greta Guarda12Department of Biochemistry, University of LausanneLudwig Center for Cancer Research of the University of LausanneDivision of Allergology and Immunology, CHUV, University of LausanneDepartment of Biochemistry, University of LausanneLudwig Center for Cancer Research of the University of LausanneDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneDivision of Allergology and Immunology, CHUV, University of LausanneCentre d’Immunologie de Marseille-Luminy, Aix-Marseille University UM2Ludwig Center for Cancer Research of the University of LausanneLudwig Center for Cancer Research of the University of LausanneDepartment of Biochemistry, University of LausanneNK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.https://doi.org/10.1038/ncomms10554
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kristina Ludigs Camilla Jandus Daniel T. Utzschneider Francesco Staehli Stéphanie Bessoles Anh Thu Dang Giorgia Rota Wilson Castro Dietmar Zehn Eric Vivier Werner Held Pedro Romero Greta Guarda
spellingShingle	Kristina Ludigs Camilla Jandus Daniel T. Utzschneider Francesco Staehli Stéphanie Bessoles Anh Thu Dang Giorgia Rota Wilson Castro Dietmar Zehn Eric Vivier Werner Held Pedro Romero Greta Guarda NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions Nature Communications
author_facet	Kristina Ludigs Camilla Jandus Daniel T. Utzschneider Francesco Staehli Stéphanie Bessoles Anh Thu Dang Giorgia Rota Wilson Castro Dietmar Zehn Eric Vivier Werner Held Pedro Romero Greta Guarda
author_sort	Kristina Ludigs
title	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_short	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_full	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_fullStr	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_full_unstemmed	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_sort	nlrc5 shields t lymphocytes from nk-cell-mediated elimination under inflammatory conditions
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-02-01
description	NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.
url	https://doi.org/10.1038/ncomms10554
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NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

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