HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

Abstract Human homologue of yeast UV excision repair protein Rad23b (HR23B) inclusions are found in a number of neurodegenerative diseases, including frontotemporal dementia (FTD), Huntington’s disease (HD), spinocerebellar ataxia type 3 and 7 (SCA3/7), fragile X associated tremor/ataxia syndrome (F...

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Bibliographic Details
Main Authors: Frederike W. Riemslagh, Hannes Lans, Harro Seelaar, Lies-Anne W. F. M. Severijnen, Shamiram Melhem, Wim Vermeulen, Eleonora Aronica, R. Jeroen Pasterkamp, John C. van Swieten, Rob Willemsen
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Acta Neuropathologica Communications
Subjects:
C9ORF72
ALS
FTD
HR23B
ERAD
NGly1
Online Access:http://link.springer.com/article/10.1186/s40478-019-0694-6

Internet

http://link.springer.com/article/10.1186/s40478-019-0694-6

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