Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer’s disease risk

Abstract Alzheimer’s disease (AD) is the most common type of dementia, affecting millions of people worldwide; however, no disease-modifying treatments are currently available. Genome-wide association studies (GWASs) have identified more than 40 loci associated with AD risk. However, most of the dis...

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Bibliographic Details
Main Authors: Gloriia Novikova, Shea J. Andrews, Alan E. Renton, Edoardo Marcora
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Molecular Neurodegeneration
Subjects:
Online Access:https://doi.org/10.1186/s13024-021-00449-0