Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

Background: Triple-negative breast cancers (TNBCs), accounting for approximately 15% of breast cancers, lack targeted therapy. A hallmark of cancer is metabolic reprogramming, with one-carbon metabolism essential to many processes altered in tumor cells, including nucleotide biosynthesis and antioxi...

Full description

Bibliographic Details
Main Authors: Michael F. Coleman, Ciara H. O’Flanagan, Alexander J. Pfeil, Xuewen Chen, Jane B. Pearce, Susan Sumner, Sergey A. Krupenko, Stephen D. Hursting
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Nutrients
Subjects:
one-carbon metabolism
triple-negative breast cancer
mitochondria
glycolysis
dietary folate
metabolomics
Online Access:https://www.mdpi.com/2072-6643/13/5/1637

Internet

https://www.mdpi.com/2072-6643/13/5/1637

Similar Items