Lupus risk variants in the PXK locus alter B-cell receptor internalization

Lupus risk variants in the PXK locus alter B-cell receptor internalization

Genome wide association studies have identified variants in PXK that confer risk for humoral autoimmune diseases, including systemic lupus erythematosus (SLE) or lupus, rheumatoid arthritis and more recently systemic sclerosis. While PXK is involved in trafficking of epidermal growth factor Receptor...

Full description

Bibliographic Details
Main Authors: Samuel E. Vaughn, Corinne eFoley, Xiaoming eLu, Zubin Hasmukh Patel, Erin E. Zoller, Albert F. Magnusen, Adrienne H. Williams, Julie T. Ziegler, Mary E. Comeau, Miranda C. Marion, Stuart B. Glenn, Adam eAdler, Nan eShen, Swapan eNath, Anne M Stevens, Barry I. Freedman, Betty P. Tsao, Chaim O. Jacob, Diane L Kamen, Elizabeth E Brown, Gary S. Gilkeson, Graciela S. Alarcón, John D. Reveille, Juan-Manuel eAnaya, Judith A. James, Kathy L. Moser, Lindsey A. Criswell, Luis M. Vilá, Marta E. Alarcon-Riquelme, Michelle ePetri, R. Hal Scofield, Robert P. Kimberly, Rosalind eRamsey-Goldman, Young eBinjoo, Jeongim eChoi, Sang-Cheol eBae, Susan A. Boackle, Timothy J. Vyse, Joel M. Guthridge, Bahram eNamjou, Patrick M. Gaffney, Carl D. Langefeld, Kenneth M. Kaufman, Jennifer A Kelly, Isaac TW Harley, John Barker Harley, Leah Claire Kottyan
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Genetics
Subjects:
B cells
lupus
BCR
Fine-mapping
PXK
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00450/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00450/full

Similar Items