TCR Repertoire Analysis Reveals Mobilization of Novel CD8+ T Cell Clones Into the Cancer-Immunity Cycle Following Anti-CD4 Antibody Administration

TCR Repertoire Analysis Reveals Mobilization of Novel CD8+ T Cell Clones Into the Cancer-Immunity Cycle Following Anti-CD4 Antibody Administration

Depletion of CD4+ cells using an anti-CD4 monoclonal antibody (anti-CD4 mAb) induces the expansion of tumor-reactive CD8+ T cells and strong antitumor effects in several murine tumor models. However, it is not known whether the anti-CD4 mAb treatment activates a particular or a broad spectrum of tum...

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Bibliographic Details
Main Authors: Hiroyasu Aoki, Satoshi Ueha, Shigeyuki Shichino, Haru Ogiwara, Shin-ichi Hashimoto, Kazuhiro Kakimi, Satoru Ito, Kouji Matsushima
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
anti-CD4 mAb
immune checkpoint inhibitor
TCR repertoire
Cancer-Immunity Cycle
Inter-Organ Clone Tracking
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03185/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03185/full

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