Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis

Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis

Colonic tissues in Inflammatory Bowel Disease (IBD) patients exhibit oxygen deprivation and activation of hypoxia-inducible factor 1α and 2α (HIF-1α and HIF-2α), which mediate cellular adaptation to hypoxic stress. Notably, macrophages and neutrophils accumulate preferentially in hypoxic regions of...

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Bibliographic Details
Main Authors: Nan Lin, Jessica E. S. Shay, Hong Xie, David S. M. Lee, Nicolas Skuli, Qiaosi Tang, Zilu Zhou, Andrew Azzam, Hu Meng, Haichao Wang, Garret A. FitzGerald, M. Celeste Simon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
inflammation
colitis
macrophages
neutrophils
hypoxia
HIF
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02565/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02565/full

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