Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML).

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML).

Aberrant epigenetic events contribute to tumorigenesis of all human cancers. Significant efforts are underway in developing new generation of epigenetic cancer therapeutics. Although clinical trials for agents targeting DNA hypermethylation and histone deacetylation have yielded promising results, d...

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Bibliographic Details
Main Authors: Xia Jiang, Cheryl Zi Hui Lim, Zhimei Li, Puay Leng Lee, Siti Maryam J M Yatim, Peiyong Guan, Juntao Li, Jianbiao Zhou, Jingxuan Pan, Wee-Joo Chng, Christina L L Chai, Qiang Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4415792?pdf=render

Internet

http://europepmc.org/articles/PMC4415792?pdf=render

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