Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening.

Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening.

Epstein-Barr Virus (EBV) latent infection is associated with several human malignancies and is a causal agent of lymphoproliferative diseases during immunosuppression. While inhibitors of herpesvirus DNA polymerases, like gancyclovir, reduce EBV lytic cycle infection, these treatments have limited e...

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Bibliographic Details
Main Authors: Ning Li, Scott Thompson, David C Schultz, Weiliang Zhu, Hualiang Jiang, Cheng Luo, Paul M Lieberman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2853575?pdf=render

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http://europepmc.org/articles/PMC2853575?pdf=render

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